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Nádorová imunoterapie založená na mechanismech vrozené imunity a studium možnosti zvýšení její účinnosti úpravou nádorového prostředí

The aim of this thesis was to study how to increase effectiveness of cancer immunotherapy based on synergy of compounds stimulating phagocytosis and TLR agonist. Tumor microenvironment was modified by enzymes, which catalised conversion of lactate to pyruvate or acetate. It was monitored effect of enzymes on tumor size, survival of experimental mice and cytotoxicity on tumor cells.

Identiferoai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:376090
Date January 2018
CreatorsMASÁKOVÁ, Kamila
Source SetsCzech ETDs
LanguageCzech
Detected LanguageEnglish
Typeinfo:eu-repo/semantics/masterThesis
Rightsinfo:eu-repo/semantics/restrictedAccess

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