The immune regulatory abilities of alveolar macrophages from C57B1/6 mice bearing a metastatic variant of Lewis lung carcinoma were determined. During early stages of tumor development, or before tumors metastasized to the lungs, alveolar macrophages did not affect or slightly enhanced T-lymphocyte proliferation; as tumor growth progressed, or following tumor metastasis, alveolar macrophages suppressed the T-cell response. Macrophage suppressor activity was probably not mediated by their production of PGE, since macrophages of tumor-bearing mice secreted less 2 PGE than did macrophages of normal mice. Normal alveolar 2 macrophages or macrophages preincubated in tumor cell supernatant for a short period stimulated T-cell blastogenesis and secreted PGE during in vitro culture. However, with 2 longer exposure to tumor cell supernatant, alveolar macrophages lost the capacity to augment T-cell proliferation and secreted less PGE 2.Ball State UniversityMuncie, IN 47306
Identifer | oai:union.ndltd.org:BSU/oai:cardinalscholar.bsu.edu:handle/183187 |
Date | 03 June 2011 |
Creators | Endicott, Roger A. |
Contributors | Young, M. Rita |
Source Sets | Ball State University |
Detected Language | English |
Format | viii, 47 leaves : ill. ; 28 cm. |
Source | Virtual Press |
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