C57B1/6 mice bearing Lewis lung carcinoma CLLC) are suppressed in their ability to generate cytotoxic T lymphocytes against the LLC tumor associated antigens. Since LLC have previously been shown to secrete the immunosuppressive factor PGE2, indomethacin, a prostaglandine synthetase inhibitor, was administered to LLC-bearing mice in their drinking water to prevent the immunosuppression typical of tumor bearers. The indomethacin treated tumor-bearers displayed an increase in their cytotoxic responses to the LLC tumor associated antigens. Thus the immunosuppression found in mice bearing LLC could be due to prostaglandin synthesis. Production of PGE2 by tumor cells may be a mechanism by which the tumors escape immune mediated destruction.Ball State UniversityMuncie, IN 47306
| Identifer | oai:union.ndltd.org:BSU/oai:cardinalscholar.bsu.edu:handle/183022 |
| Date | 03 June 2011 |
| Creators | Hoover, Cathy S. |
| Contributors | Young, M. Rita |
| Source Sets | Ball State University |
| Detected Language | English |
| Format | viii, 41 leaves ; 28 cm. |
| Source | Virtual Press |
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