Ubiquitin fold modifier 1 (Ufm1) is a member of the ubiquitin like protein (UBL) family. Like other UBLs, Ufm1 can be conjugated to protein substrates via specific E1 (Uba5), E2 (Ufc1) and E3 (Ufl1) enzymes, and removed from these substrates via the action of Ufm1-specific proteases. While Ufm1 has been implicated in endoplasmic reticulum (ER) function, its biological roles remain poorly understood. By identifying; (a) Ufm1 binding proteins, (b) protein interactors of the Ufm1 conjugation/deconjugation system, (c) Ufm1 conjugates, as well as (d) the intracellular localization of Ufm1 and its main interactors, I aimed to better characterize the biological role(s) of this poorly understood UBL.
| Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/42952 |
| Date | 28 November 2013 |
| Creators | Tehami, Yasmina |
| Contributors | Raught, Brian |
| Source Sets | University of Toronto |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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