Infection of the human urinary tract is one of the commonest bacterial infections, with
uropathogenic E.coli (UPEC) being responsible for 90% of the diagnosed cases, with significant morbidity and mortality. The urinary bladder is a remarkable autonomic
musculomembranous organ under conscious control. Its two main functions are, storage
and voiding of urine. Any disturbance to normal urination leads to various clinical
conditions, such as urinary incontinence, bladder retention, overactive bladder syndrome, prostatitis in men and urinary tract infections (UTI). Determining the predisposition of an individual to UTI by discovering a biomarker would allow for a more rational selection of patients who might best benefit from either antibiotic prophylaxis or preemptive surgical intervention. The purpose of this study was to examine the epigenetic effects of UPEC infection directly, or indirectly in the bladder. The study also identified potential
gene candidates, such as TLR4 and CTCF, for development of DNA methylation biomarker targets.
| Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/65611 |
| Date | 07 July 2014 |
| Creators | Vincent, Akshita K |
| Contributors | Bagli, Darius J |
| Source Sets | University of Toronto |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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