V3 interneurons in the spinal cord are a group of excitatory commissural interneurons that play an important role in producing balanced and stable gaits in animals. We discovered that Sim1-expressing V3 interneurons arise from the ventral-most progenitor domain in the developing neural tube and migrate in a dorso-lateral trajectory to settle into three distinct subpopulations. The most ventral subpopulation projects axons in both an rostral and caudal direction, while the intermediate and dorsal subpopulations are mostly rostrally-projecting. The role of Sim1 as a transcription factor was shown to play a role both in the proper migration and axon projection of V3 interneurons.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:NSHD.ca#10222/34629 |
| Date | 26 July 2013 |
| Creators | Blacklaws, Jake |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
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