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Alometrijos metodų taikymas ekstrapoliuojant antimaliarinės medžiagos farmakokinetinius parametrus į žmogų / The use of the allometric methods in extrapolation of the pharmacokinetic parameters of compound antipaludic to the man

Every year Malaria ruins millions of lives. Can we change it? There are more and more resistant Malaria forms so efficacy of drugs is lesser. I participated on non clinical trials with new malaria drug in France, Montpellier1 University, faculty of pharmacy, clinical pharmacokinetic laboratory. It’s always necessary investigate pharmacokinetic parameters (clearance, half-life, volume of distribution etc.) in study with animals. Can we calculate these parameters to human using parameters of animals? In this work you can find malaria aetiology and epidemiology, the ways how to protect from this disease and revue of drugs for treatment. There you can find structure-activity action of new molecule. Also there explained choice of analytical method and allometry. In practice part of my work there is quantity analysis and preparation for it, stability and method validation results. Analytical samples prepared with pig’s, dog’s, monkey’s, rat’s and mouce’s plasma. All calculated pharmacokinetic parameters were used in allometric analysis and extrapolation to the man. The main tasks of my work were: • Calculate concentration and pharmacokinetic parameters for animals; • Verify allometric relation for the new drug; • Calculate pharmacokinetic parameters for the man by using allometric methods. From obtained information we can indicate prior drug absorbsion, metabolism and efficacy to the man.

Identiferoai:union.ndltd.org:LABT_ETD/oai:elaba.lt:LT-eLABa-0001:E.02~2006~D_20060710_103139-23354
Date10 July 2006
CreatorsLukšys, Nerijus
ContributorsBriedis, Vitalis, Radžiūnas, Raimundas, Bressolle, Francoise, Savickienė, Nijolė, Savickas, Arūnas, Kaunas University of Medicine
PublisherLithuanian Academic Libraries Network (LABT), Kaunas University of Medicine
Source SetsLithuanian ETD submission system
LanguageLithuanian
Detected LanguageEnglish
TypeMaster thesis
Formatapplication/pdf
Sourcehttp://vddb.library.lt/obj/LT-eLABa-0001:E.02~2006~D_20060710_103139-23354
RightsUnrestricted

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