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Mechanistic understanding of competitive destabilization of carbamazepine cocrystals under solvent free conditions

No / Mechanistic understanding of competitive destabilization of carbamazepine:nicotinamide and carbamazepine:saccharin cocrystals under solvent free conditions has been investigated. The crystal phase transformations were monitored using hot stage microscopy, variable-temperature powder X-ray diffraction, and sublimation experiments. The destabilization of the two cocrystals occurs via two distinct mechanisms: vapor and eutectic phase formations. Vapor pressure measurements and thermodynamic calculations using fusion and sublimation enthalpies were in good agreement with experimental findings. The mechanistic understanding is important to maintain the stability of cocrystals during solvent free green manufacturing. / EPSRC (EP/J003360/1, EP/ L027011/1). MHD. Bashir would like to thank CARA for providing doctoral degree scholarship.

Identiferoai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/18061
Date22 August 2020
CreatorsAlsirawan, M.H.D. Bashir, Lai, X., Prohens, R., Vangala, Venu R., Shelley, P., Bannan, T.J., Topping, D.O., Paradkar, Anant R
Source SetsBradford Scholars
LanguageEnglish
Detected LanguageEnglish
TypeArticle, No full-text in the repository

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