Background: Malaria causes over 400,000 estimated deaths annually worldwide, with about 90% in sub-Saharan Africa. Long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) are two vector-control interventions proven to reduce malaria transmission, but their use together compared to separate has shown mixed results.
Methodology: We used a mathematical model to examine the impact of LLINs and IRS on malaria transmission. Time-series analyses and basic reproductive numbers (R0) were developed using MATLAB. We also assessed IRS timing and performed a sensitivity analysis on R0.
Results: Modelling scenarios combining LLINs with IRS were similar to those with LLINs alone. Shorter IRS impulses had greater reductions in mosquito populations. The LLIN feeding-inhibition rate was a key parameter with a negative correlation to R0.
Discussion/Conclusion: We developed an understanding of the effect of vector-control strategies on malaria transmission. IRS, when paired with LLINs, showed only small improvements in reducing malaria transmission compared to LLINs alone. These results can assist vector-control programmes.
| Identifer | oai:union.ndltd.org:uottawa.ca/oai:ruor.uottawa.ca:10393/35376 |
| Date | January 2016 |
| Creators | Tomayer, Andrew |
| Contributors | Smith, Robert, Kulkarni, Manisha |
| Publisher | Université d'Ottawa / University of Ottawa |
| Source Sets | Université d’Ottawa |
| Language | English |
| Detected Language | English |
| Type | Thesis |
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