Oral anticoagulants (OACs) are indicated in the first-line treatment of venous thromboembolism (VTE), which comprises of deep vein thrombosis (DVT) and pulmonary embolism (PE). While contemporary guidelines recommend extended-duration anticoagulation after the first diagnosis of unprovoked VTE, the benefits and harms associated with this approach remain unclear across age groups, especially among older adults. Crucially, contemporary estimates of VTE recurrence have not incorporated all-cause mortality as a competing event, the risk of which increases with age. Therefore, we evaluated and synthesized existing literature on of the risk of all-cause mortality by age following completion of limited-duration anticoagulation for a first episode of unprovoked VTE. In addition, we determined the risk of VTE recurrence after completion of limited-duration OAC therapy by age, with death as a competing outcome using data from a prospective cohort study.
| Identifer | oai:union.ndltd.org:uottawa.ca/oai:ruor.uottawa.ca:10393/45318 |
| Date | 23 August 2023 |
| Creators | Xu, Yan |
| Contributors | Carrier, Marc, Le Gal, Grégoire |
| Publisher | Université d'Ottawa / University of Ottawa |
| Source Sets | Université d’Ottawa |
| Language | English |
| Detected Language | English |
| Type | Thesis |
| Format | application/pdf |
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