La Enfermedad de Carrión, es causada por la bacteria Bartonella bacilliformis, que se transmite por varias especies del insecto vector del género Lutzomyia. No se conoce ningún reservorio animal, aparentemente el hombre es el único. Es una enfermedad endémica en el Perú y actualmente es considerada como reemergente debido a que su área geográfica se viene expandiendo. Es importante estudiar marcadores moleculares que sirvan para el diseño de métodos de diagnóstico rápido y efectivos, así como evaluar los antibióticos recomendados como medidas terapéuticas contra esta enfermedad, e indagar más acerca de las proteínas antigénicas de esta bacteria a fin de seleccionar antígenos candidatos para desarrollar, una vacuna contra esta enfermedad o pruebas de diagnóstico para su detección de laboratorio de mayor sensibilidad y especificidad que las actuales. IalB y FlaA son proteínas interesantes debido a su participación en la invasión bacteriana al eritrocito humano. / Carrion’s Disease is caused by Bartonella bacilliformis bacterium, and is transmitted by several species of the vector insect of the Lutzomyia genus. Animal reservoir is not known; seemingly the man is the only one. This disease is endemic in Peru and is actually considered as re-emergent because their geographical distribution comes expanding. Thus it is important to study its molecular markers for established diagnosis methods that are quick and effective. On the treatment aspect, it is necessary to evaluate the antibiotics used against the disease. On the therapeutic topic, more research is required regarding the antigenic proteins from this bacterium; this fact is important to develop future vaccine against this disease or diagnostic assay for their detection in the laboratory or to improve the sensitivity and specificity of the current methods. IalB and FlaA are interesting proteins due to than they are involved in the bacterial invasion to the human erythrocyte. / Tesis
| Identifer | oai:union.ndltd.org:Cybertesis/oai:cybertesis.unmsm.edu.pe:cybertesis/975 |
| Date | January 2008 |
| Creators | Flores Aguilar, Lidia Escolástica |
| Contributors | Del Valle Mendoza, Luis Javier |
| Publisher | Universidad Nacional Mayor de San Marcos |
| Source Sets | Universidad Nacional Mayor de San Marcos - SISBIB PERU |
| Language | Spanish |
| Detected Language | English |
| Type | info:eu-repo/semantics/bachelorThesis |
| Format | application/pdf |
| Source | Universidad Nacional Mayor de San Marcos, Repositorio de Tesis - UNMSM |
| Rights | info:eu-repo/semantics/openAccess |
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