Mycoplasma hyopneumoniae is the causative agent of the respiratory disease Swine Enzootic Pneumonia, a mild chronic lower respiratory tract infection that affects pig populations world wide. The disease causes decreased growth rates and poor feed conversion in infected pigs and results in significant economic losses. While several swine enzootic pneumonia vaccines arc available, none are totally effective. These current vaccines are based on bacterins or cell fractions. As yet, no commercial vaccines composed of recombinant subunits are available. Prior to the commencement of this study, three candidate vaccinc antigens had been identified in this laboratory, from the Australian M. hyopneumoniae field isolate Beaufort. The three proteins (48 kDa, 52 kDa and 74 kDa) reacted with antibody secreting cell probes, derived from hyper-immune swine lung tissue, indicating they are important in the local antibody response to M. hyopneumoniae infection. (For complete abstract open document)
| Identifer | oai:union.ndltd.org:ADTP/245401 |
| Creators | Doughty, Stephen William |
| Source Sets | Australiasian Digital Theses Program |
| Language | English |
| Detected Language | English |
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