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Temperature dependent stiffness and visco-elastic behaviour of lipid coated microbubbles using atomic force microscopy.

Yes / The compression stiffness of a phospholipid microbubble was determined using force-spectroscopy as a function of temperature. The stiffness was found to decrease by approximately a factor of three from 0.08 N m 1, at 10 C, down to 0.03 N m 1 at 37 C. This temperature dependence indicates that the surface tension of lipid coating is the dominant contribution to the microbubble stiffness. The timedependent material properties, e.g. creep, increased non-linearly with temperature, showing a factor of two increase in creep-displacement, from 24 nm, at 10 C, to 50 nm, at 37 C. The standard linear solid model was used to extract the visco-elastic parameters and their determination at different temperatures allowed the first determination of the activation energy for creep, for a microbubble, to be determined. / EPSRC

Identiferoai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/5491
Date03 November 2011
CreatorsGrant, Colin A., McKendry, J.E., Evans, S.D.
Source SetsBradford Scholars
LanguageEnglish
Detected LanguageEnglish
TypeArticle, Published version
Rights© 2012 RSC Publishing. Reproduced in accordance with the publisher's self-archiving policy. Archived 12 months after accepted by date: Accepted 30th September 2011, Unspecified

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