All populations risk vitamin D inadequacy. We conducted a randomized double- blind trial of vitamin D3 fortified cheddar cheese to study bioavailability based on serum 25-hydroxyvitamin D [25(OH)D] concentrations, and its effects on mental health scores in older adults. Once a week, 28 subjects received 200 IU or 28000 IU of vitamin D3 per fortified cheese serving. The mean increases in 25(OH)D over 8 weeks were: 4.2±11.4 and 29.4±16.2 for the 200 IU/week and 28,000 IU/ week dose groups, respectively (groups differ, P<0.001). Subjects who consumed 28,000 IU/week cheese improved their Mental Component Summary (MCS) scores, based upon the SF-36v2 questionnaire conducted at baseline and at 8 weeks (P<0.05). There was also a positive correlation between the change in MCS score and the change in 25(OH)D (1 tail; P<0.05). These data demonstrate the suitability of fortified cheddar cheese, and provide evidence of neurocognitive benefits with higher 25(OH)D levels.
| Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/33551 |
| Date | 27 November 2012 |
| Creators | Taha, Nadeen |
| Contributors | Vieth, Reinhold |
| Source Sets | University of Toronto |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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