The influence of riboflavin doses on the urinary excretion of
riboflavin and 4-pyridoxic acid was investigated in 6 young men.
Doses of crystalline riboflavin and/or pyridoxine were administered
on days 10 to 25 using a 6 X 6 Latin square design. The 6
crystalline vitamin doses given were: 0.3 mg and 0.6 mg pyridoxine;
1.2 mg and 2.4 mg riboflavin: 0.3 mg pyridoxine with 1.2 mg
riboflavin and 0.6 mg pyridoxine with 2.4 mg riboflavin. On day 28
each subject received 0.06 mg riboflavin. On days 30 to 45, 6 food
doses of known riboflavin content were administered to the subjects
using a 6 X 6 Latin square design. All crystalline vitamin and food
doses were separated by two days. All subjects consumed a constant
diet during the experimental period. Twenty-four-hour urine
collections were made throughout the study. Urinary riboflavin
excretion increased in response to the 1.2 mg and 2.4 mg riboflavin
doses but not after the 0.06 mg dose. Urinary riboflavin excretion
increased after the milk dose only. Bioavailability of riboflavin in non-fat dry milk, which was estimated by reference to the riboflavin
dose response curve, was 61 ± 35 (mean ± S.D.) percent. In 4 of the
6 subjects urinary 4-pyridoxic acid excretion was suppressed when
riboflavin was administered with pyridoxine. Additionally, in four
subjects the 2.4 mg riboflavin dose depressed urinary 4-pyridoxic
acid excretion to a level below that seen with the 1.2 mg riboflavin
dose. These results provide additional supporting evidence for a
riboflavin/vitamin B-6 interaction. / Graduation date: 1985
| Identifer | oai:union.ndltd.org:ORGSU/oai:ir.library.oregonstate.edu:1957/27230 |
| Date | 02 May 1985 |
| Creators | Ottinger, Joan Marie |
| Contributors | Miller, Lorraine T. |
| Source Sets | Oregon State University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis/Dissertation |
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