by Lam Heung-wah, Angora. / Thesis (M. Phil.)--Chinese University of Hong Kong, 1992. / Includes bibliographical references (leaves 124-131). / ACKNOWLEDGEMENTS --- p.iv / ABSTRACT --- p.v / LIST OF ABBREVIATIONS --- p.vii / LIST OF TABLES --- p.viii / LIST OF FIGURES --- p.ix / INTRODUCTION --- p.1 / LITERATURE REVIEW --- p.4 / Chapter A. --- Some Aspects of Cardiovascular Physiology and Pharmacology --- p.4 / Chapter I. --- Fundamental Principles Governing regulation of Arterial Pressure --- p.4 / Chapter II. --- Hypertension --- p.12 / Chapter III. --- Antihypertensive Substances --- p.16 / Chapter B. --- Mushrooms and Their Medicinal Values --- p.29 / Chapter I. --- "The Straw Mushroom, V. volvacea" --- p.29 / Chapter II. --- "Mushrooms, Blood Pressure, and Related Changes" --- p.32 / MATERIALS AND METHODS --- p.39 / Chapter A. --- Basic Preparative Procedures --- p.39 / Chapter I. --- Preparation of Straw Mushroom Extract (SME) --- p.39 / Chapter II. --- Purification of SME by Dialysis --- p.40 / Chapter III. --- Preparation for In vivo Blood Pressure Measurement in Rats --- p.40 / Chapter IV. --- preparation of Right Atrium for In vitro Studies --- p.41 / Chapter V. --- Preparation of Artery Strip for In vitro Studies --- p.42 / Chapter B. --- Experiments Done --- p.43 / Chapter Experiment 1. --- Toxicity of SME --- p.43 / Chapter Experiment 2. --- Hypotensive Effect of SME and Dialyzed Samples --- p.44 / Chapter Experiment 3. --- Pharmacological Antagonist Studies --- p.45 / Chapter Experiment 4. --- Effect of Autonomic Ganglion Blocker and Alpha Blocker on Hypotensive Changes Induced by SME --- p.47 / Chapter Experiment 5. --- Study on Renin-Angiotensin and Kinin Systems --- p.48 / Chapter Experiment 6. --- Urinary and Sodium Excretion in Water-loaded Rats --- p.48 / Chapter Experiment 7. --- Chronotropic and Inotropic Studies on Isolated Right Atria --- p.49 / Chapter Experiment 8. --- Contractile Responses of SME & Its Dialyzed Samples on Rat Tail Artery Strips --- p.50 / Chapter Experiment 9. --- Effect of Adrenergic Blockers in SME Preconstricted Strips --- p.51 / Chapter Experiment 10. --- Acute Oral Effect of DUL8000 and DLL8000 from SME on Blood Pressure --- p.51 / Chapter Experiment 11. --- "Chronic Oral Effect of SME on Blood Pressure, Total Free Cholesterol and Triglyceride Levels" --- p.52 / Chapter C. --- Statistics --- p.55 / RESULTS --- p.56 / Chapter A. --- Toxicity of Straw Mushroom Extract (SME) --- p.56 / Chapter B. --- Effects of SME in Normotensive Rats --- p.56 / Chapter I. --- Blood Pressure Changes --- p.56 / Chapter II. --- Pharmacological Antagonists Studies --- p.58 / Chapter III. --- Converting Enzyme Activity --- p.60 / Chapter IV. --- Urinary and Sodium Excretion --- p.60 / Chapter V. --- In vitro Arterial and Cardiac Effects --- p.61 / Chapter C. --- Cardiovascular Effects of Dialyzed Samples of SME (Molecular Mass cutoffl2000) in Spontaneously Hypertensive Rats (SHR) and Normotensive Rats --- p.61 / Chapter I. --- Blood Pressure Changes --- p.61 / Chapter II. --- In vitro Arterial and Cardiac Effects --- p.62 / Chapter D. --- Cardiovascular Effects of Dialyzed Samples (DUL8000 and DLL8000) in Spontaneously Hypertensive Rats (SHR) and Normotensive Rats --- p.63 / Chapter I. --- Blood Pressure Changes --- p.63 / Chapter II. --- In vitro Arterial and Cardiac Effects --- p.65 / Chapter E. --- The Acute Oral Effect of SME on Blood Pressure --- p.68 / Chapter F. --- "Chronic Dietary Effect of SME on Blood Pressure, Total Free Serum Cholesterol and Triglyceride Levels" --- p.68 / DISCUSSION --- p.109 / Chapter A. --- The Hypotensive Effect of SME --- p.109 / Chapter B. --- The Hypotensive Action of SME: Mechanism of Action --- p.110 / Chapter C. --- The Cardiovascular Active Fractions in SME --- p.113 / Chapter D. --- "The Cardiovascular Effect of DUL8000 and DLL8000 in Rats with Reference to Age, Sex and Strains" --- p.115 / Chapter E. --- The Oral Effect of SME on Blood Pressure and on Serum Cholesterol and Triglyceride Levels --- p.118 / SUMMARY --- p.121 / REFERENCES --- p.124 / APPENDIXES --- p.132
| Identifer | oai:union.ndltd.org:cuhk.edu.hk/oai:cuhk-dr:cuhk_319207 |
| Date | January 1992 |
| Contributors | Lam, Heung-wah Angora., Chinese University of Hong Kong Graduate School. Division of Biology. |
| Publisher | Chinese University of Hong Kong |
| Source Sets | The Chinese University of Hong Kong |
| Language | English |
| Detected Language | English |
| Type | Text, bibliography |
| Format | print, xi, 152 leaves : ill. ; 30 cm. |
| Rights | Use of this resource is governed by the terms and conditions of the Creative Commons “Attribution-NonCommercial-NoDerivatives 4.0 International” License (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
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