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Reakcia na poškodenie DNA v zelených riasach Chlamydomonas reinhardtii a Scenedesmus quadricauda / DNA damage response in green algae Chlamydomonas reinhardtii and Scenedesmus quadricauda

The effect of FdUrd, zeocin, caffeine and their combination on the cell cycle of green algae Chlamydomonas reinhardtii and Scenedesmus quadricauda and response of these model organisms to DNA damage were studied. Both, FdUrd and zeocin, caused DNA damage that led to cell cycle arrest in these algae. In contrast, caffeine partially abolished G2 phase block imposed by zeocin. Protein levels of three crucial cell cycle regulators - CdkA, CdkB and Wee1 kinases were measured to identify mechanisms controlling reaction to DNA damage.

Identiferoai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:55342
Date January 2011
CreatorsHLAVOVÁ, Monika
Source SetsCzech ETDs
LanguageSlovak
Detected LanguageEnglish
Typeinfo:eu-repo/semantics/doctoralThesis
Rightsinfo:eu-repo/semantics/restrictedAccess

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