Dyslexia is a common condition among both children and adults in the United States. Its prevalence is estimated to be between 5% and 17% of school-aged children. This chronic condition is characterized by a difficulty in reading unanticipated in children with otherwise average or above average intelligence, education and incentive. Although adults with a specific reading disability have demonstrated diminished diffusion anistropy, this relationship between reading ability and white matter connectivity is relatively unexplored in children. In this study, diffusion tensor magnetic resonance imaging (MRI) was utilized to compare the white matter connectivity in three groups of children with diverse reading ability- dysfluent and inaccurate (n= 42), dysfluent and accurate (n= 69) and nonimpaired (n= 23) children. ANOVA statistical analysis was performed detect any significant group differences in anisotropic indices between the three groups of readers. In contrast to past studies, our study did not reveal any statistically significant differences in fractional anisotropy, fiber coherence index and mean diffusivity between dysfluent and inaccurate, dysfluent but accurate, and non-impaired readers.
| Identifer | oai:union.ndltd.org:YALE_med/oai:ymtdl.med.yale.edu:etd-06282006-105511 |
| Date | 30 March 2007 |
| Creators | Klang, Kendra Marie |
| Contributors | Bennett Arthur Shaywitz MD |
| Publisher | Yale University |
| Source Sets | Yale Medical student MD Thesis |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://ymtdl.med.yale.edu/theses/available/etd-06282006-105511/ |
| Rights | mixed, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Yale School of Medicine or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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