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The influence of insulin-like growth factor 1 and its analogues on fibroblasts and dermal wound healing

Includes bibliography (leaves 191-219). Examines the levels of insulin-like growth factor and the presence of IGF binding proteins in human wound fluid. Tests the potency of IGF-1 and 2 analogues in in vitro models of fibroblast activity and their effect on healing in normal and diabetic rodent wounds. Shows that IGF-1, IGF-2 and their binding proteins are present in fluid from a partial thickness cutaneous wound; that the binding proteins negatively modulate the activity of insulin-like growth factors in vitro, but that the IGFs do not necessarily show enhanced activity in vivo at the wound site if binding protein affinity is decreased. Discusses possible roles of these binding proteins in wound repair.

Identiferoai:union.ndltd.org:ADTP/100075
Date January 1998
CreatorsMarshall, Nicholas John.
Source SetsAustraliasian Digital Theses Program
LanguageEnglish
Detected LanguageEnglish
RelationSUA

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