<p>X-ray micro-CT is widely used for small animal imaging in preclinical studies of cardiopulmonary disease, but further development is needed to improve spatial resolution, temporal resolution, and material contrast. This study presents a set of tools that achieve these improvements. These tools include the mathematical formulation and computational implementation of algorithms for calibration, image reconstruction, and image analysis with our custom micro-CT system. These tools are tested in simulations and in experiments with live animals. With these tools, it is possible to visualize the distribution of a contrast agent throughout the body of a mouse as it changes over time, and produce 5-dimensional images (3 spatial dimensions + time + energy) of the cardiac cycle.</p> / Dissertation
| Identifer | oai:union.ndltd.org:DUKE/oai:dukespace.lib.duke.edu:10161/5589 |
| Date | January 2012 |
| Creators | Johnston, Samuel Morris |
| Contributors | Badea, Cristian T |
| Source Sets | Duke University |
| Detected Language | English |
| Type | Dissertation |
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