Yes / Ynamides, though relatively more stable than ynamines, are still moisture-sensitive and prone to hydration especially under acidic and heating conditions. Here we report an environmentally benign, robust protocol to synthesize sulfonamide-based ynamides and arylynamines via Sonogashira coupling reactions in water, using a readily available quaternary ammonium salt as the surfactant. / This work was supported by Royal Society - Newton International Fellowship (170322), National Natural Science Foundation of China (21462004), the State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources at Guangxi Normal University (CMEMR2014-A04).
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/18428 |
| Date | 30 March 2021 |
| Creators | Zhao, L., Yang, H., Li, R., Tao, Y., Guo, X-F., Anderson, E.A., Whiting, A., Wu, Na |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article, Accepted manuscript |
| Rights | © 2020 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Organic Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.joc.0c02326., Unspecified |
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