Crystallisation of pure anhydrous polymorphs of carbamazepine by solution enhanced dispersion with supercritical fluids (SEDS¿).

Description

No / Pure anhydrous polymorphs of carbamazepine were prepared by solution-enhanced dispersion with supercritical fluids (SEDSTM). Crystallization of the polymorphs was studied. Mechanisms are proposed that consider the thermodynamics of carbamazepine, supersaturation in the SEDSTM process, and the binary phase equilibria of organic solvents and the carbon dioxide antisolvent. -Carbamazepine was crystallized at high supersaturations and low temperatures, -carbamazepine crystallized from a methanol-carbon dioxide phase split, and -carbamazepine crystallized via nucleation at high temperatures and low supersaturation.

Links & Downloads

1. Edwards, A.D., Shekunov, B.Y., Kordikowski, A., Forbes, R.T. and York, P (2001). Crystallisation of pure anhydrous polymorphs of carbamazepine by solution enhanced dispersion with supercritical fluids (SEDS¿). Journal of Pharmaceutical Sciences. Vol. 90, No. 8, pp. 1115-1124.
2. http://hdl.handle.net/10454/3977
3. https://doi.org/10.1002/jps.1065

Tags

Crystallization

SEDS

Dispersion

Polymorphism

Additional Fields

Identifer	oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/3977
Date	January 2001
Creators	Edwards, Anthony D., Shekunov, Boris Yu., Kordikowski, Andreas, Forbes, Robert T., York, Peter
Source Sets	Bradford Scholars
Language	English
Detected Language	English
Type	Article, No full-text in the repository