EVALUATION OF AMINOINDOLE CARBOXAMIDES AND TRIAZINES AS POTENTIAL ANTI-AGGREGATION AGENTS OF PROTEIN MISFOLDING DISEASES

Description

<p dir="ltr">My research projects focuses on the dual targeting of small molecules to abrogate aberrant α-syn, tau (2N4R), and p-tau (1N4R) aggregation and to reduce the spread of AD and related dementias. Not very many drug discovery programs focus on the specific isoforms of the tau protein. We established two series of compounds: aminoindole compounds connected by a carboxamide and triazine compounds connected by a triazine linker. Using biophysical methods we evaluated the effectiveness of both series of compounds in decreasing the amount of misfolded α-syn and tau protein in order to explore their anti-aggregation potential.</p><p><br></p>

Links & Downloads

1. 10.25394/pgs.25685910.v1

Tags

Central nervous system

Basic pharmacology

Alzheimer's disease

Amide

alpha-synuclein (synuclein alpha)

fibril

oligomer

tau isoform 2n4r

anti-aggregation compounds

hyperphosphorylated protein tau

paired helical filaments

drug discovery

triazine compound

Additional Fields

Identifer	oai:union.ndltd.org:purdue.edu/oai:figshare.com:article/25685910
Date	06 May 2024
Creators	Eduardo Ramirez (18436542)
Source Sets	Purdue University
Detected Language	English
Type	Text, Thesis
Rights	CC BY 4.0
Relation	https://figshare.com/articles/thesis/EVALUATION_OF_AMINOINDOLE_CARBOXAMIDES_AND_TRIAZINES_AS_POTENTIAL_ANTI-AGGREGATION_AGENTS_OF_PROTEIN_MISFOLDING_DISEASES/25685910