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High-Frequency Irreversible Electroporation (H-FIRE) optimization for the treatment of highly invasive cells beyond the tumor margin

Irreversible electroporation (IRE) is a non-thermal ablation technique that allows for eradication of unresectable tumors in a minimally invasive procedure. While IRE will preferentially kill larger cells over smaller ones, it does not discriminate between cells with larger and small nuclei. Given that one of the hallmarks of cancer cell morphology is larger, more abundant nuclei, our team set out to explore the possibility of preferentially targeting this physical and geometrical characteristic. / Master of Science

Identiferoai:union.ndltd.org:VTETD/oai:vtechworks.lib.vt.edu:10919/81131
Date19 June 2016
CreatorsLatouche, Eduardo L.
ContributorsEngineering Science and Mechanics, Davalos, Rafael V., Lesko, John J., Rossmeisl, John H. Jr., Verbridge, Scott
PublisherVirginia Tech
Source SetsVirginia Tech Theses and Dissertation
Detected LanguageEnglish
TypeThesis
FormatETD, application/pdf
RightsIn Copyright, http://rightsstatements.org/vocab/InC/1.0/

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