Magnetic particles offer attractive features, so its development in a wide range of disciplines, including medical applications, has been very fruitful. As a result of the special physical properties of magnetic nanoparticles, many potential applications are made available in biomedicine. The most important feature of these particles is its magnetic forces, and it has been utilized in applications such as magnetic separation, drug delivery, hyperthermia and magnetic resonance imaging contrast agent. The important properties of magnetic particles for biomedical applications are nontoxicity, biocompatiblilty, injectability, and high-level accumulation in the target tissue or organ to two most important property among those mentioned above are nontoxicity and biocompatiblilty for available clinical trials. Some researchers have used polymers or polysaccharides coating on these surface of the magnetic material to improve the material's nontoxicity and biocompatiblilty. Common materials are dextran, polyethylene glycol, polyvinyl alcohol, starch and chitin and so on. We embedd Fe3O4 magnetic nanoparticles into agar hydrogels in the experiment, then made into powder by drying and grinding, using XRD, FTIR, TEM, SQUID, TGA and zeta potential identification of material properties. We examined its toxicity and the possibility for large scale production. This method can make use of simple and inexpensive way to mass-produce synthetic these biocompatible magnetic materials.
| Identifer | oai:union.ndltd.org:NSYSU/oai:NSYSU:etd-0809110-153053 |
| Date | 09 August 2010 |
| Creators | Huang, Bo-yau |
| Contributors | Michael Y. Chiang, Shuchen Hsieh, Shu-Ling Hsieh |
| Publisher | NSYSU |
| Source Sets | NSYSU Electronic Thesis and Dissertation Archive |
| Language | Cholon |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0809110-153053 |
| Rights | not_available, Copyright information available at source archive |
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