Biochemical theories postulate that deficient serotonergic functioning may be etiologically related to affective illness and aggressive behavior. In Study I mood and aggressivity were measured in thirty-six normal male subjects before and after ingestion of a Tryptophan Depleted, Tryptophan Loaded or Balanced amino acid mixture. While no differences in aggressivity were found, the Tryptophan Depleted group scored significantly higher at posttest on the MAACL Depression Scale than the control groups and demonstrated selective attention for dysphoric themes. In Study II a Balanced or Tryptophan Depleted amino acid mixture was administered to eighty normal male subjects prior to placing them in either a positive or negative environment, with or without instructions concerning the potential amino acid effects. The tryptophan depleted group became significantly more depressed than the control group regardless of environmental condition or instructional set. These findings suggest that lowered tryptophan may result in a central serotonergic dysfunction which is causally related to depressive affect and possibly to the pathogenesis of clinical forms of depression.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.71991 |
| Date | January 1985 |
| Creators | Smith, Scott E. (Scott Edward) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy (Department of Psychology.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 000220581, proquestno: AAINL20854, Theses scanned by UMI/ProQuest. |
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