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The significance of telomere length in the elderly.

Suen, Wai Chiu. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2009. / Includes bibliographical references (leaves 117-128). / Abstract also in Chinese. / ACKNOWLEDGEMENTS --- p.ii / LIST OF ABBREVIATIONS --- p.iii / ABSTRACT --- p.v / 摘要 --- p.vii / LIST OF PUBLICATIONS --- p.viii / TABLE OF CONTENTS --- p.ix / Chapter CHAPTER 1. --- INTRODUCTION --- p.1 / Chapter 1.1. --- Nature of Telomeres / Chapter 1.1.1. --- Telomere structure --- p.1 / Chapter 1.1.2. --- Importance of telomeres --- p.2 / Chapter 1.1.3. --- Telomere length attrition during replicative senescence --- p.3 / Chapter 1.1.4. --- Telomere length maintenance --- p.6 / Chapter 1.1.5. --- "Oxidative stress, inflammatory process and telomere length" --- p.7 / Chapter 1.1.6. --- Telomere attrition rate --- p.8 / Chapter 1.2. --- "Age, Gender and Telomere Length" / Chapter 1.2.1. --- Age and telomere length --- p.10 / Chapter 1.2.2. --- Gender difference of telomere length --- p.10 / Chapter 1.3. --- Health Status and Telomere Length --- p.13 / Chapter 1.3.1. --- Coronary heart diseases --- p.13 / Chapter 1.3.2. --- Cancers --- p.14 / Chapter 1.3.3. --- Infections and chronic inflammation --- p.15 / Chapter 1.3.4. --- Bone mineral density --- p.16 / Chapter 1.3.5. --- Neurodegenerative diseases --- p.17 / Chapter 1.3.6. --- Frailty and mortality --- p.19 / Chapter 1.4. --- "Lifestyles, Environment and Telomere Length" --- p.21 / Chapter 1.4.1. --- Obesity --- p.21 / Chapter 1.4.2. --- Smoking --- p.22 / Chapter 1.4.3. --- Physical activity --- p.23 / Chapter 1.4.4. --- Diet --- p.23 / Chapter 1.4.5. --- Psychological stress --- p.24 / Chapter 1.4.6. --- Socioeconomic status --- p.24 / Chapter 1.5. --- Methods of Measuring Telomere Length --- p.27 / Chapter 1.6. --- Aims and Hypotheses of the Study --- p.31 / Chapter 1.6.1. --- Aims --- p.31 / Chapter 1.6.2. --- Hypotheses --- p.31 / Chapter CHAPTER 2. --- SUBJECTS AND METHODS --- p.33 / Chapter 2.1. --- Subjects Recruitment --- p.34 / Chapter 2.2. --- Interview --- p.34 / Chapter 2.3. --- Anthropometry --- p.35 / Chapter 2.4. --- DNA Extraction and Storage --- p.35 / Chapter 2.5. --- Telomere Length Measurement --- p.37 / Chapter 2.5.1. --- Terminal restriction fragment analysis --- p.37 / Chapter 2.5.2. --- Quantitative real-time PCR --- p.39 / Chapter 2.6. --- Self-perceived Health --- p.46 / Chapter 2.7. --- Medical History --- p.46 / Chapter 2.8. --- Bone Mineral Density --- p.47 / Chapter 2.9. --- Frailty Index --- p.47 / Chapter 2.10. --- Mortality Rate --- p.50 / Chapter 2.11. --- Smoking --- p.50 / Chapter 2.12. --- Physical Activity --- p.51 / Chapter 2.13. --- Dietary Intakes --- p.51 / Chapter 2.15. --- Socioeconomic Status --- p.52 / Chapter 2.16. --- Statistical Analysis --- p.53 / Chapter CHAPTER 3. --- RESULTS AND DISCUSSIONS --- p.55 / Chapter 3.1. --- Demographics --- p.55 / Chapter 3.2. --- Telomere Length Distribution --- p.64 / Chapter 3.2.1. --- Age and telomere length --- p.64 / Chapter 3.2.2. --- Gender and telomere length --- p.68 / Chapter 3.3. --- Health Status and Telomere Length --- p.71 / Chapter 3.3.1. --- Self-perceived health --- p.71 / Chapter 3.3.2 --- History of diseases --- p.74 / Chapter 3.3.3. --- Bone mineral density --- p.80 / Chapter 3.3.4. --- Frailty index --- p.86 / Chapter 3.3.5. --- Mortality rate --- p.91 / Chapter 3.4. --- "Lifestyles, Environment and Telomere Length" --- p.94 / Chapter 3.4.1. --- Smoking --- p.94 / Chapter 3.4.2. --- Physical activity --- p.99 / Chapter 3.4.3. --- Diet --- p.104 / Chapter 3.4.4. --- Socioeconomic status --- p.109 / Chapter CHAPTER 4. --- CONCLUSIONS --- p.115 / Chapter 4.1. --- General conclusions --- p.115 / Chapter 4.2 --- The Significance of telomere length in the elderly --- p.115 / Chapter 4.3. --- Future Works and Prospect --- p.116 / References --- p.117

Identiferoai:union.ndltd.org:cuhk.edu.hk/oai:cuhk-dr:cuhk_326910
Date January 2009
ContributorsSuen, Wai Chiu., Chinese University of Hong Kong Graduate School. Division of Medical Sciences.
Source SetsThe Chinese University of Hong Kong
LanguageEnglish, Chinese
Detected LanguageEnglish
TypeText, bibliography
Formatprint, xii, 128 leaves : ill. ; 30 cm.
RightsUse of this resource is governed by the terms and conditions of the Creative Commons “Attribution-NonCommercial-NoDerivatives 4.0 International” License (http://creativecommons.org/licenses/by-nc-nd/4.0/)

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