Using an operant-olfactometer, the long term learning and memory, executive function,
olfactory sensitivity, and working memory of the 5XFAD mouse model of Alzheimer’s
disease was assessed. Six month old male and female 5XFAD and wildtype mice were
tested. No deficits were found on an olfactory discrimination task or a reversal learning
task. Female and transgenic mice performed better than male and wildtype mice on the
higher odour concentrations, but not the lower concentrations, of the sensitivity task,
suggesting differences in learning rate or maximum performance on the task, but not
olfactory detection. This study demonstrated for the first time that mice are able to learn
an olfactory delayed matching to sample task with delays up to 30 seconds long. Female
mice showed higher levels of performance on the matching to sample task than male
mice, indicative of better working memory.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:NSHD.ca#10222/15269 |
| Date | 24 July 2012 |
| Creators | Roddick, Kyle |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
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