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Amniotic fluid fatty acids and cholesterol and their association with pregnancy outcomes

The objectives were (1) to establish a profile of total fatty acids and cholesterol in amniotic fluid (AF) as well as (2) to determine possible associations between AT fatty acids (micromolar and relative proportion) with gestational age and birth weight. A total of 208 AF samples collected between 12 and 22 weeks of gestation during routine amniocentesis were analyzed using tandem column gas chromatography (GC). Smoking increased AF polyunsaturated fatty acid (PUFAs) levels while developmental stage and storage time decreased AF fatty acid quantities. AF trans fatty acids (TFAs) were negatively associated with both birth outcomes, whereas specific fatty acids including stearic acid (C18:0) and gondoic acid (C20:1n-9) were identified as negative predictors for gestational age and birth weight respectively. This study demonstrated novel relationships between fatty acids and fetal growth and gestational age in early midgestation AF, suggesting a possible role of AF fatty acids in predicting birth outcomes.

Identiferoai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.99341
Date January 2006
CreatorsEnros, Erin.
PublisherMcGill University
Source SetsLibrary and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada
LanguageEnglish
Detected LanguageEnglish
TypeElectronic Thesis or Dissertation
Formatapplication/pdf
CoverageMaster of Science (School of Dietetics and Human Nutrition.)
Rights© Erin Enros, 2006
Relationalephsysno: 002573360, proquestno: AAIMR28486, Theses scanned by UMI/ProQuest.

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