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Previous issue date: 2008-01-17 / The purpose of this study was to compare the effectiveness and duration of the analgesic tramadol to the morphine, administered by the epidural route in cats (Felis catus domesticus) For this, six females cats were used, without defined breed, weighing between three and four kilograms and age ranging from one to three years. After fasting food, in 12 hours and water, four hours, the animals were subjected to general anesthesia with isoflurane through an anesthetic box, in order to allow the completion of the epidural technique. Each animal received at random, in a blind study, three epidural route treatments at intervals of one week between them, with: saline solution to 0.9% in a volume equivalent to 0.22ml.kg-1 (Control Group), tramadol 1 mg.kg-1 diluted in saline solution and volume equivalent to 0.22 ml.kg-1 (Tramadol Group) and morphine 0.1mg.kg-1 diluted in saline solution and volume equivalent to 0.22ml.kg-1 (Morphine Group). One hour after administration of each drug and general anesthesia recovery, the animals were subjected to painful stimuli in three pre-defined places: in the dorsal tail basis, the side of the right and left thigh, giving continuity, 2, 3, 4, 6, 8, 10 and 12 hours respectively. The pain was qualified by the implementation of two Simple Descriptive Scales (SDS), a Visual Analog Scale (VAS), measurement of heart and respiratory rate. For qualitative variables used in the Latin Square design 3 x 3 with the Kruskal-Wallis test and for the quantitative variables used in Analysis of Variance (ANOVA). There was no difference in relation to the time of anesthesia and respiratory frequency, However, the heart rate was significantly different (p<0.05) in hours two and four between control group and tramadol. In all scales used there were significant difference (p<0.05) in hours 8, 10 and 12. In these times the morphine produced more quality analgesia than the tramadol. Based on the results obtained, it can be concluded that the tramadol administered in epidural route resulted a satisfactory analgesia, without an adverse effects, but poorer than the morphine analgesia administered by the same route. / O objetivo do presente estudo foi comparar a efic?cia e dura??o analg?sica do tramadol ?s da morfina, administrados por via epidural em gatos (Felis catus domesticus). Para tanto, utilizaram-se seis f?meas da esp?cie felina, sem ra?a definida, com peso entre tr?s a quatro quilos e idade variando de um a tr?s anos. Ap?s o jejum alimentar, de 12 horas e h?drico, de quatro horas, os animais foram submetidos ? anestesia geral com isoflurano por meio de uma c?mara anest?sica, com a finalidade de realizar a t?cnica epidural, evitando o estresse. Cada animal recebeu de forma aleat?ria, em um estudo cego, tr?s tratamentos por via epidural com intervalos de uma semana entre estes, com: solu??o salina a 0,9% num volume equivalente a 0,22ml.kg-1 (Grupo Controle), tramadol 1mg.kg-1 dilu?do em solu??o salina e volume equivalente a 0,22ml.kg-1 (Grupo Tramadol) e morfina 0,1mg.kg-1 dilu?do em solu??o salina e volume equivalente a 0,22ml.kg-1 (Grupo Morfina). Uma hora ap?s a administra??o de cada f?rmaco e o completo retorno da anestesia geral, os animais foram submetidos a est?mulos dolorosos em tr?s locais pr?-definidos: base da cauda, face lateral da coxa direita e esquerda, dando continuidade, 2, 3, 4, 6, 8, 10 e 12 horas respectivamente. A dor foi qualificada pela implementa??o de duas Escalas Simples Descritivas (SDS), uma Escala Anal?gica Visual (VAS), mensura??o da freq??ncia card?aca e respirat?ria. Para as vari?veis qualitativas utilizou-se o delineamento em Quadrado Latino 3 x 3 com o teste de Kruskal-Wallis e para as quantitativas a An?lise de Vari?ncias (ANOVA). N?o houve diferen?a em rela??o ao tempo de anestesia e freq??ncia respirat?ria, entretanto, houve diferen?a estat?stica significante (p<0,05) na freq??ncia card?aca nas horas dois e quatro entre os animais do grupo controle e do tramadol. Em todas as escalas utilizadas houve diferen?a significante (p<0,05) nas horas 8, 10 e 12, sendo que a morfina apresentou qualidade analg?sica superior ao do tramadol nesses momentos. Com base nos resultados obtidos, pode-se concluir que o tramadol administrado por via epidural resultou analgesia satisfat?ria, isenta de efeitos adversos, por?m inferior ? analgesia da morfina, administrada pela mesma via.
| Identifer | oai:union.ndltd.org:IBICT/oai:localhost:tede/887 |
| Date | 17 January 2008 |
| Creators | Castro, Douglas dos Santos e |
| Contributors | Scherer, Paulo Oldemar, Silva, Marta Fernanda Albuquerque da |
| Publisher | Universidade Federal Rural do Rio de Janeiro, Curso de P?s-Gradua??o em Medicina Veterin?ria, UFRRJ, Brasil, Cl?nica e Cirurgia Veterin?ria |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da UFRRJ, instname:Universidade Federal Rural do Rio de Janeiro, instacron:UFRRJ |
| Rights | info:eu-repo/semantics/openAccess |
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