Endocrine disrupting chemicals (EDCs) of exogenous origin refer to compounds that disrupt the regular functioning of the endocrine system responsible for maintaining hormonal balance in the body. These disruptors are prevalent in our surroundings and are present in various consumer products, including cosmetics, plastics, and pesticides. The means of action vary depending on the specific chemical and target hormone receptor. EDCs can mimic, obstruct, alter hormone production, transport, and metabolize, leading to a range of health risks such as metabolic disorders, immune system dysfunction, and endocrine-related cancers, as well as reproductive abnormalities. Interference with the production, transport, and function of hormones responsible for the menstrual cycle and pregnancy, including estrogen, progesterone, and luteinizing hormone, leads to reproductive problems. EDCs also cause permanent alterations in the development of the female reproductive system during fetal and early childhood stages. Some of the most widely known EDCs include bisphenol-A (BPA), phthalates, and polychlorinated biphenyls (PCBs), which have been found in human tissue and fluids, such as urine and breast milk.
Researchers continue to discover and analyze EDC prevalence and the effects on human health. While efforts have been made to reduce exposure to these compounds, they remain prevalent in the environment. There are lifestyle interventions that can help with the prevention and exposure to EDCs. Such interventions include healthier eating habits, avoiding the use of plastic containers containing EDCs, choosing safer personal care products, filtering drinking water, reducing exposure to air pollution, and supporting policies and regulations that promote the use of safer chemicals.
| Identifer | oai:union.ndltd.org:bu.edu/oai:open.bu.edu:2144/48217 |
| Date | 26 February 2024 |
| Creators | Frazier, Gabrielle E. |
| Contributors | Tornheim, Keith, Lane, Sandra |
| Source Sets | Boston University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis/Dissertation |
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