Concanavalin A with the property enhances T-cell activation have been known. BALB/c mice infected with Angiostrongylus cantonensis administrated with different doses 2.5mg/kg, 5mg/kg, 10mg/kg and vehicle from 7th day to 10th day p.i. and administrated with a single dose 5mg/kg at different period started from 7th day to 10th day, 14th day to 17th day,21th day to 24th day p.i. Effects of concanavalin A on Angiostrongylus cantonensis infected mice was determined by counting the percentage of eosinophil in blood, measuring the worm length, protein density in cerebro-spinal fluid, ELISA, and histological observation. Concanavalin A injection promotes eosinophila in Angiostrongylus cantonensis infected mice, antibody response and inhibits larvae growth. Protein density in CSF decrease when 10mg/kg dose given and period given from14th day to 17th day,period given from 21th day to 24th day. And hemorrhage in brain tissue was reduced.
| Identifer | oai:union.ndltd.org:NSYSU/oai:NSYSU:etd-0620106-214819 |
| Date | 20 June 2006 |
| Creators | Wu, Yu-shuo |
| Contributors | none, none, David Chao |
| Publisher | NSYSU |
| Source Sets | NSYSU Electronic Thesis and Dissertation Archive |
| Language | Cholon |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0620106-214819 |
| Rights | unrestricted, Copyright information available at source archive |
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