Buprenorphine is a promising medication for the treatment of opiate abuse. The pharmacology of buprenorphine has been studied in vitro using radioligand binding and [³⁵S]GTPγS assays, and in vivo using assays of antinociception in rodents. A number of compounds with potential similar pharmacology have also been characterised. These are an iso-morphinan pyrrolidine derivative, and long-lasting 14-aminomorphinones and codeinones, in particular clocinnamox (C-CAM), a pure μ-antagonist and methoclocinnamox (MC-CAM), which has some agonist properties.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:311041 |
| Date | January 1999 |
| Creators | Neilan, Claire L. |
| Publisher | Loughborough University |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Source | https://dspace.lboro.ac.uk/2134/14129 |
Page generated in 0.2549 seconds