Pharmacokinetic parameters for theophylline and
dyphylline were evaluated in horse cerebrospinal fluid
(csf) and plasma. Pharmacokinetic parameters did not
differ significantly (p > 0.05) at the same dose for
either drug when administered alone or concomitantly.
Theophylline and dyphylline penetrate horse csf to
produce approximately 1/2 the concentrations found in
plasma. Doubling the theophylline dose from 10 mg/Kg to
20 mg/Kg doubled both csf and plasma theophylline
concentrations. However, doubling the dyphylline dose
from 20 mg/Kg to 40 mg/Kg tripled both csf and plasma
dyphylline concentrations. Simultaneous fitting between
plasma and csf drug concentrations indicates that plasma
is a good indicator for predicting csf concentrations for
both theophylline and dyphylline.
The influence of ibuprofen input rate on antipyresis
was studied in rats with yeast induced fever. In
addition, a data analysis comparison was made between rat
data collected from this present study and literature
data from fevered children. Counterclockwise hysteresis
curves (ibuprofen plasma concentration versus temperature
decrement) were observed following ibuprofen oral
suspension when administered to rats and children. When
the collapsed hysteresis curves were plotted (mean
predicted total ibuprofen effect compartment
concentration versus mean predicted temperature decrement
effect) the rat and children's curves were not
superimposable. However, the collapsed hysteresis curves
of mean predicted ibuprofen unbound effect concentration
versus mean predicted temperature decrement effect were
superimposable for data from the rats and children.
Based on mean unbound ibuprofen effect compartment
concentration versus mean predicted temperature decrement
effect, the antipyretic response to ibuprofen appears to
be comparable between rats and children. The apparent
qualitative trend in temperature decrement, although not
statistically significant, perhaps due to variability,
appears to be different among ibuprofen input regimens in
rats. Maximum temperature decrement appears to relate
not just to the concentration of ibuprofen obtained at
steady-state, but the rate at which it is obtained. / Graduation date: 1993
| Identifer | oai:union.ndltd.org:ORGSU/oai:ir.library.oregonstate.edu:1957/36820 |
| Date | 20 August 1992 |
| Creators | Stevens, Ruth E. |
| Contributors | Ayres, James W. |
| Source Sets | Oregon State University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis/Dissertation |
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