Biološka aktivnost novosintetisanih D-seko i D-homo-estratrienskih derivata u in vivo i in vitro uslovima / Biological activity of the newly synthesized D-secoand D-homoestratriene derivatives in in vivo and in vitro experiments

Description

<p>Sintetisana su nova jedinjenja, 16- i 17-supstituisani&nbsp;16,17-sekoestratrienski derivati i D-homoestranski&nbsp;derivati, polazeći od 3-benziloksi-17-hidroksi-16,17-sekoestra-1,3,5(10)-trien-16-nitrila. Ispitana je&nbsp;estrogena i antiestrogena aktivnost u eksperimentima <em>in&nbsp;vivo</em>, antiaromatazna aktivnost <em>in vitro</em>, antioksidantna&nbsp;aktivnost DPPH &nbsp;i TBA testom, kao i antiproliferativna&nbsp;aktivnost prema ćelijskim linijama MCF-7 ATCC,&nbsp;MDA-MB-231, HT-29 i MRC-5 novosintetisanih&nbsp;jedinjenja.</p> / <p>Some new compounds, 16- and 17-substituted 16,17-secoestratriene derivatives, as&nbsp; well as D-homoestratriene derivatives, were synthesized, starting from 3-benzyloxy-17-hydroxy-16,17-secoestra-1,3,5 (10)-triene-16-nitrile. The newly synthesized compounds were tested for their <em>in vivo&nbsp;</em>estrogenic and antiestrogenic activity,&nbsp; <em>in vitro&nbsp;</em>antiaromatase activity, antioxidative activity by DPPH and TBA tests, as well as antiproliferative activity against MCF-7 ATCC, MDA-MB-231, HT-29 i MRC-5 cell lines.</p>

Links & Downloads

1. https://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija139592377199093.pdf?controlNumber=(BISIS)82649&fileName=139592377199093.pdf&id=1663&source=NDLTD&language=en
2. https://www.cris.uns.ac.rs/record.jsf?recordId=82649&source=NDLTD&language=en
3. http://dx.doi.org/10.2298/NS20101008JOVANOVICSANTA
4. http://vbs.rs/scripts/cobiss?command=SEARCH&base=99999&select=ID=259698183

Tags

Additional Fields

Identifer	oai:union.ndltd.org:uns.ac.rs/oai:CRISUNS:(BISIS)82649
Date	08 October 2010
Creators	Jovanović-Šanta Suzana
Contributors	Mimica-Dukić Neda, Sakač Marija, Kovačević Radmila, Popović Milan
Publisher	Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, University of Novi Sad, Faculty of Sciences at Novi Sad
Source Sets	University of Novi Sad
Language	Serbian
Detected Language	English
Type	PhD thesis