<p>Sintetisana su nova jedinjenja, 16- i 17-supstituisani 16,17-sekoestratrienski derivati i D-homoestranski derivati, polazeći od 3-benziloksi-17-hidroksi-16,17-sekoestra-1,3,5(10)-trien-16-nitrila. Ispitana je estrogena i antiestrogena aktivnost u eksperimentima <em>in vivo</em>, antiaromatazna aktivnost <em>in vitro</em>, antioksidantna aktivnost DPPH i TBA testom, kao i antiproliferativna aktivnost prema ćelijskim linijama MCF-7 ATCC, MDA-MB-231, HT-29 i MRC-5 novosintetisanih jedinjenja.</p> / <p>Some new compounds, 16- and 17-substituted 16,17-secoestratriene derivatives, as well as D-homoestratriene derivatives, were synthesized, starting from 3-benzyloxy-17-hydroxy-16,17-secoestra-1,3,5 (10)-triene-16-nitrile. The newly synthesized compounds were tested for their <em>in vivo </em>estrogenic and antiestrogenic activity, <em>in vitro </em>antiaromatase activity, antioxidative activity by DPPH and TBA tests, as well as antiproliferative activity against MCF-7 ATCC, MDA-MB-231, HT-29 i MRC-5 cell lines.</p>
Identifer | oai:union.ndltd.org:uns.ac.rs/oai:CRISUNS:(BISIS)82649 |
Date | 08 October 2010 |
Creators | Jovanović-Šanta Suzana |
Contributors | Mimica-Dukić Neda, Sakač Marija, Kovačević Radmila, Popović Milan |
Publisher | Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, University of Novi Sad, Faculty of Sciences at Novi Sad |
Source Sets | University of Novi Sad |
Language | Serbian |
Detected Language | English |
Type | PhD thesis |
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