<p>U prvom delu ove doktorske disertacije je izvršena<br />sinteza novih derivata androstana sa D-laktonskom<br />funkcijom ili D-seko derivata, sa modifikacijama u Ai/<br />ili B-prstenovima. U drugom delu je ispitana<br />antiproliferativna aktivnost odabranih<br />novosintetizovanih jedinjenja prema humanim<br />tumorskim ćelijskim linijama (MCF-7, MDA-MB-231,<br />PC-3, HeLa, HT-29, K562) kao i prema zdravim<br />ćelijama fetalnih fibroblasta pluća (MRC-5).</p> / <p>In first part of this work was achieved synthesis of some new androstane derivatives with D-lactone function and new D-seco derivatives with modification in A and/or B rings. In the second part the antiproliferative activity of selected newly synthesized compounds by human carcinoma cell lines (MCF-7, MDA-MB-231, PC-3, HeLa, HT-29, K562) and the healthy cells of fetal lung fibroblasts (MRC-5 ) was examined.</p>
| Identifer | oai:union.ndltd.org:uns.ac.rs/oai:CRISUNS:(BISIS)82689 |
| Date | 19 March 2013 |
| Creators | Savić Marina P. |
| Contributors | Đurendić Evgenija, Penov-Gaši Katarina, Sakač Marija, Csanádi János, Djilas Sonja |
| Publisher | Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, University of Novi Sad, Faculty of Sciences at Novi Sad |
| Source Sets | University of Novi Sad |
| Language | Serbian |
| Detected Language | English |
| Type | PhD thesis |
| Format | application/pdf |
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