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Antitumour Imidazotetrazines: Past, Present... and Future?

Yes / It is 40 years since the publication of the patent that announced the imidazotetrazines temozolomide
and mitozolomide to the world and 30 since the discovery that they function as prodrugs
of alkyldiazonium reactive intermediates. Temozolomide combined with radiation is established as the
first-line treatment for glioma but despite the attentions of the inventors and others, further examples of
this intriguing ring system have yet to enter the clinic.

Identiferoai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/19592
Date19 September 2023
CreatorsStevens, M.F.G., Wheelhouse, Richard T.
Source SetsBradford Scholars
LanguageEnglish
Detected LanguageEnglish
TypeArticle, Published version
Rights© 2023 The Author(s). This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence., CC-BY-NC

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