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Příprava fluorovaných karbocyklických derivátů nukleosidů jako potenciálních inhibitorů virové replikace / Preparation of fluorinated carbocyclic derivatives of nucleosides as potential viral replication inhibitors

This master thesis is dedicated to the preparation of fluorinated derivatives of carbocyclic nucleosides, that may serve as flaviviral replication inhibitors. Preparation of both monofluorinated as well as gem-difluorinated analogs of ribo and 2'-deoxyribonucleoside was attempted. While a suitable and reliable route for the preparation of monofluorinated compounds way found, synthesis of gem-difluorinated turned out to be rather challenging. Although most of the presented work dealt with compounds bearing adenine as a nucleobase, the universal applicability of the developed procedures, demonstrated on the preparation of a guanosine-type molecule, suggests that after slight optimization larger series of this type of compounds could be prepared.

Identiferoai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:406273
Date January 2019
CreatorsŠtefek, Milan
ContributorsNencka, Radim, Šimák, Ondřej
Source SetsCzech ETDs
LanguageCzech
Detected LanguageEnglish
Typeinfo:eu-repo/semantics/masterThesis
Rightsinfo:eu-repo/semantics/restrictedAccess

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