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Structure-Activity Studies on the Simplified Analog of Aplysiatoxin and Identification of the PKC Isozymes Involved in Its Anti-Proliferative Activity / アプリシアトキシン単純化アナログの構造活性相関とがん細胞増殖抑制に関わるPKCアイソザイムの同定

京都大学 / 0048 / 新制・課程博士 / 博士(農学) / 甲第21153号 / 農博第2279号 / 新制||農||1059(附属図書館) / 学位論文||H30||N5127(農学部図書室) / 京都大学大学院農学研究科食品生物科学専攻 / (主査)教授 入江 一浩, 教授 保川 清, 教授 橋本 渉 / 学位規則第4条第1項該当 / Doctor of Agricultural Science / Kyoto University / DFAM

Identiferoai:union.ndltd.org:kyoto-u.ac.jp/oai:repository.kulib.kyoto-u.ac.jp:2433/232354
Date26 March 2018
CreatorsHanaki, Yusuke
Contributors入江, 一浩, 保川, 清, 橋本, 渉, 花木, 祐輔, ハナキ, ユウスケ
PublisherKyoto University, 京都大学
Source SetsKyoto University
LanguageEnglish
Detected LanguageEnglish
Typedoctoral thesis, Thesis or Dissertation
Formatapplication/pdf
RightsStructure-activity studies at position 27 of aplog-1, a simplified analog of debromoaplysiatoxin with anti-proliferative activity (Tetrahedron, September 2013, Volume 69, Issue 36, pp7636-7645, doi: 10.1016/j.tet.2013.02.008) "Loss of the Phenolic Hydroxyl Group and Aromaticity from the Side Chain of Anti-Proliferative 10-Methyl-Aplog-1, a Simplified Analog of Aplysiatoxin, Enhances Its Tumor-Promoting and Proinflammatory Activities" (Molecules, April 2017, Volume 22, Issue 4, pp631, doi: 10.3390/molecules22040631) "Identification of protein kinase C isozymes involved in the anti-proliferative and pro-apoptotic activities of 10-Methyl-aplog-1, a simplified analog of debromoaplysiatoxin, in several cancer cell lines" (Biochemical and Biophysical Research Communication, January 2018, Volume 495, Issue 1, pp438-445, doi: 10.1016/j.bbrc.2017.11.052)
Relationhttps://doi.org/10.1016/j.tet.2013.02.008, https://doi.org/10.3390/molecules22040631, https://doi.org/10.1016/j.bbrc.2017.11.052

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