Angiogenesis is an essential physiological process involved in wound repair, endometrial growth and embryogenesis and is tightly regulated in normal tissues. However, angiogenesis is also associated with some pathological conditions; in these conditions, angiogenesis eludes regulation and presents as either unabated (as in diabetic retinopathy and neoplasia), or as an inefficient process (as in ischaemic coronary disease). Regardless of this, all angiogenic mechanisms have a common biological basis, ergo, the shift of anti-angiogenic research has been towards biologically-based angiogenesis inhibitors; it is well established that these anti-angiogenic paradigms can be applied to inhibit the growth of solid neoplasms. / Antagonists of tumour-associated angiogenesis from a diverse range of sources have been identified and analysed, including agents capable of eliciting an apoptotic response in the endothelial cells lining the tumour vasculature. Tumour-associated microvascular endothelial cells, although derived from normal, host endothelial cells, exhibit differential characteristics which are able to be exploited, in order to induce endothelial cell apoptosis in tumour vessels, while normal, host vessels remain unaffected. / Thesis (PhDBiomedicalScience)--University of South Australia, 2005.
| Identifer | oai:union.ndltd.org:ADTP/286466 |
| Creators | Bateman, Emma Hazel |
| Source Sets | Australiasian Digital Theses Program |
| Language | English |
| Detected Language | English |
| Rights | copyright under review |
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