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Immunosuppressive protocol with delayed use of low-dose tacrolimus after aortic transplantation suppresses donor-specific anti-MHC class I and class II antibody production in rats

Background: Arterial allografts are used as vascular conduits in the treatment of prosthetic graft infection. Immunosuppression
decreases their rupture risk rate. However, immunosuppression can be unprofitable in florid infection. Previously, we confirmed inhibition of cell-mediated destruction of rat aortic grafts by delayed use of tacrolimus. In this work, we studied the influence of this protocol on the antibody-mediated rejection.

Identiferoai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:13298
Date January 2014
CreatorsMatia, Ivan, Fellmer, Peter, Splith, Katrin, Varga, Martin, Adamec, Milos, Kämmerer, Ines, Feldbrügge, Linda, Krenzien, Felix, Hau, Hans-Michael, Atanasov, Georgi, Schmelzle, Moritz, Jonas, Sven
ContributorsUniversitätsklinikum Leipzig, Institute for Clinical and Experimental Medicine, Annals of transplantation
Source SetsHochschulschriftenserver (HSSS) der SLUB Dresden
LanguageEnglish
Detected LanguageEnglish
Typedoc-type:article, info:eu-repo/semantics/article, doc-type:Text
SourceAnnals of transplantation 2014, 19:225-232
Rightsinfo:eu-repo/semantics/openAccess

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