The chicken ductus arteriosi (DA) are two embryonic blood vessels that shunt blood away from the non-ventilated lungs and towards the body and chorioallantoic membrane. I show that prostaglandins have a diminished role in maintaining chicken DA patency and nitric oxide inhibits oxygen induced contraction of the day 19 proximal DA in a time dependent manner. The pathways governing oxygen induced contraction in the chicken DA are similar to those found in mammals and include contributions from ROS, Kv channels, L-type Ca2+ channels, and the Rho kinase pathway. Longer exposure to high oxygen generates increased oxygen induced constriction of the day 19 DA that may be mediated through the Rho kinase pathway.
| Identifer | oai:union.ndltd.org:unt.edu/info:ark/67531/metadc5173 |
| Date | 12 1900 |
| Creators | Greyner, Henry José |
| Contributors | Dzialowski, Edward M. (Edward Michael), Burggren, Warren W., Burleson, Mark |
| Publisher | University of North Texas |
| Source Sets | University of North Texas |
| Language | English |
| Detected Language | English |
| Type | Thesis or Dissertation |
| Format | Text |
| Rights | Public, Copyright, Greyner, Henry José, Copyright is held by the author, unless otherwise noted. All rights reserved. |
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