Purpose: To determine whether reduced serum levels of AHSG and elevated levels of BMP-2,
4, 7 are associated with post-arthroplasty HO. Patients: Thirty arthroplasty patients were
included, 15 with evidence of peri-articular HO and 15 without (NHO). Methods: Blood
samples were collected from all patients ≥ 8 weeks after arthroplasty. Analytes were measured
using ELISAs. Mann-Whitney U tests were performed to compare serum analyte concentrations
between HO and NHO groups, and between arthroplasty patients and healthy humans. Results:
There is no difference in serum concentrations of AHSG, BMP-2, 4, 7 between HO and NHO
patients. Arthroplasty patients showed significantly higher BMP-2 and BMP-4 and lower AHSG
serum levels compared to healthy humans (p < 0.01). Conclusion: Baseline BMP-2, 4, 7 and
AHSG serum levels are not markers of acquired HO. However, elevated baseline levels of BMP-
2, 4 and reduced levels of AHSG appear to be markers of severe inflammatory arthritis.
Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/25405 |
Date | 14 December 2010 |
Creators | Albilia, Jonathan |
Contributors | Tenenbaum, Howard, Clokie, Cameron |
Source Sets | University of Toronto |
Language | en_ca |
Detected Language | English |
Type | Thesis |
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