Objective: This study aimed to examine the current available peer-reviewed evidence in order to gain insight into the most effective procedures used for the early identification and monitoring of aminoglycoside (AG)-induced cochleotoxicity and to suggest a protocol based on these findings. Method: Several databases were sourced with a comprehensive search conducted on Pubmed, Scopus and Medline (Ovid) to identify peer-reviewed studies published in English up until March 2020. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines were adhered to. Studies were subjected to pre-set inclusion and exclusion criteria in order to eliminate the possibility of effects other than AG/s influencing auditory functioning. The reference lists of the included studies were also screened. Results: Twenty-one studies met the inclusion criteria for the systematic review and were analysed. The majority of the studies used conventional pure tone audiometry (PTA) with only a few studies using extended high frequencies (EHF/s) and otoacoustic emission (OAE) testing. Conclusion: Since the damaging effect of AG/s is evident at the outer hair cells (OHC/s) of the basal end of the cochlea first, EHF audiometry and distortion product otoacoustic emissions (DPOAE/s) testing seems more promising for the early detection and monitoring of AG-induced cochleotoxicity. For effective and efficient identification and monitoring of AG-induced cochleotoxicity, a test battery comprising of a combination of subjective and objective measures, specifically aimed at the OHC/s by means of EHF audiometry and OAE-testing (DPOAE specifically) and possibly speech-in-noise (SPIN) tests such as the digits-in-noise (DIN) / SPIN-tests, is recommended as a standard protocol. / Dissertation (MA (Audiology))--University of Pretoria, 2020. / Speech-Language Pathology and Audiology / MA (Audiology) / Unrestricted
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:up/oai:repository.up.ac.za:2263/77019 |
| Date | January 2020 |
| Creators | Botha, Larraine |
| Contributors | Soer, Maggi E. (Magdalena Elizabeth), larrainev377@gmail.com, Heinze, Barbara M. |
| Publisher | University of Pretoria |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Dissertation |
| Rights | © 2019 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
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