Caenorhabditis elegans optionally enter into a dauer diapause phase that results
in a prolonged life in a semi-dormant state. Entry into and recovery from dauer diapause
includes many physical changes in body structure, physiology, and gene expression.
Entry into dauer diapause is regulated by several signaling pathways including
transforming growth factor (TGF-β). Autophagy plays an important role in dauer
formation and recover. During dauer transformation autophagy is up-regulated and may
play a role in remodeling the molecular structure for long term survival during dauer
diapause. This research helps determine the role of autophagy in dauer development and
recovery mediated through the TGF-β signaling pathway. This research also determines
in which tissue autophagy is necessary for dauer formation and recovery through TGF-β signaling. This research is shedding light on the function of autophagy in the TGF-β
signaling pathway, both processes of which have been linked to tumorigenesis, heart
disease and cancer. / Includes bibliography. / Thesis (M.S.)--Florida Atlantic University, 2017. / FAU Electronic Theses and Dissertations Collection
| Identifer | oai:union.ndltd.org:fau.edu/oai:fau.digital.flvc.org:fau_38049 |
| Contributors | Ritter, Portia (author), Jia, Kailiang (Thesis advisor), Florida Atlantic University (Degree grantor), Charles E. Schmidt College of Science, Department of Biological Sciences |
| Publisher | Florida Atlantic University |
| Source Sets | Florida Atlantic University |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation, Text |
| Format | 42 p., application/pdf |
| Rights | Copyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder., http://rightsstatements.org/vocab/InC/1.0/ |
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