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Search for Surrogate Marker(s) of Immunity Following Vaccination with Experimental Vaccine (Autoclaved Leishmania Major + Bacille Calmette-Guérin) in Human Volunteers

Cutaneous leishmaniasis (CL) is usually a self-limiting lesion on the skin while visceral leishmaniasis is a progressive, systemic disease with high mortality even if treated. The problem associated with treatment and vector control justifies a search for an effective vaccine which seems to be the only practical means to control the disease. The aim of this study is to identify immunological surrogate marker(s) associated with protection against Leishmania infection. The results indicate that a single dose of ALM+BCG induced Thl-like response but the level of such response is not sufficient for full protection. Accordingly, further evaluation of the vaccine is necessary other strategies multiple injections or changing the adjutant.

Identiferoai:union.ndltd.org:unt.edu/info:ark/67531/metadc935616
Date12 1900
CreatorsMahmoodi, Majid
ContributorsO'Donovan, Gerard A., Khamesipour, Ali, Shanley, Mark Stephen, Theriot, L. J., Schneider, Daniel H.
PublisherUniversity of North Texas
Source SetsUniversity of North Texas
LanguageEnglish
Detected LanguageEnglish
TypeThesis or Dissertation
Formatx, 174 leaves : ill., Text
RightsPublic, Mahmoodi, Majid, Copyright, Copyright is held by the author, unless otherwise noted. All rights

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