It has been proposed within recent years that the neurotoxin of Clostridium botulinum might exert its effect in the animal body by interfering with the synthesis or release of acetylcholine at myoneural junctions. The object of this study was to determine whether or not botulinum toxin inhibits the bacterial acetylation of choline. No effect upon the synthesis or release of acetylcholine by Lactobacillus plantarum was demonstrated. It may be that the large toxin molecule is unable to penetrate the cell membrane. The apparent activity of a bacterial cell-free "extract" of the enzyme involved in the acetylation of choline indicates however the advisability of further work.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.122735 |
| Date | January 1950 |
| Creators | Girvin, Grace T. |
| Contributors | Burgen, A. (Supervisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science. (Department of Bacteriology and Immunology.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | Theses scanned by McGill Library. |
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