Benzylpenicillin, a-aminobenzylpenicillin, phenoxymethylpenicillin, and 2,6-dimethoxy-phenylpenicillin were incubated with whole human blood. Migration patterns into human erythrocytes were compared spectrophotometrically.A possible inhibition effect by chloroquine on benzyl-[14C]-penicillin in red blood cells was studied via a Beckman LS-100C Liquid Scintillation Counter.An intraerythrocytic protein, carbonic anhydrase, was investigated as being responsible for the hydrolysis of benzylpenicillin. Three carbonic anhydrases (a, b, and c) were quantitatively measured via a Beckman IR 4250 Spectrophotometer for their effect upon the a-lactam ring of benzylpenicillin.Ball State UniversityMuncie, IN 47306
Identifer | oai:union.ndltd.org:BSU/oai:cardinalscholar.bsu.edu:handle/182090 |
Date | 03 June 2011 |
Creators | Lauper, Bonnie Lu |
Contributors | Wagner, Eugene S. |
Source Sets | Ball State University |
Detected Language | English |
Format | iv, 55 leaves : ill. ; 28 cm. |
Source | Virtual Press |
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