The poultry industry has been using antibiotics to enhance bird performance through the control of microbial agents in the gastrointestinal tract; however antibiotic alternatives must be investigated. The effect of yeast-derived products such as brewer’s yeast (Y), yeast cell wall polysaccharide-rich product (YCW), wheat/corn distiller dried grains with solubles (DDGS), nucleotide-rich product (N), processed yeast/nucleotide-rich product (PY+N) and D+mannose (M) was assessed using chicken B cells (DT40 cell line) and a LPS challenge model. Relative gene expression of toll-like receptors (TLR) and cytokines was then characterized.. These results show that yeast and yeast-derived products stimulate LPS-challenged B cells to produce Th2-associated cytokines which may lead to in vivo antibody production and gram-negative bacteria clearance. Furthermore, the up-regulation of IL-10 caused by the presence of Y, DDGS, N and PY+N is an important finding as it illustrates the regulatory activity stimulated by these treatments in the presence of Escherichia coli-derived LPS.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:MWU.1993/8161 |
| Date | 14 August 2012 |
| Creators | Echeverry, Harold |
| Contributors | Rodriguez, Juan Carlos (Animal Science), Slominski, Bogdan (Animal Science) Crow, Gary (Animal Science) Holley, Rick (Food Science) |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Detected Language | English |
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