Many psychiatric disorders are characterized by difficulties in working towards long-term goals. Effort-based decision-making (EBDM) provides a useful framework for understanding this phenomenon, particularly for parsing motivation into various components, and exploring the underpinnings of cost-benefit computations. Importantly, large changes in arousal, like those introduced by strong emotions and stress, can significantly influence high-order cognitive processes. However, the mechanistic properties underlying associations between emotions and various components of EBDM remain unclear, particularly at psychological, neurological and endocrinological levels. The following experiments were designed to examine the effect of positive and negative emotions on various components of EBDM across psychiatric conditions characterized by motivational and impulse-related deficits. In the first experiment, comparing emotional versus behavioural inhibitory systems in binge eating disorder, inverse relationships between disgust sensitivity, inhibitory control and binge-eating behaviours were found, suggesting unique maintenance functions of cognitive-affective links with emotion regulation on eating attitudes. In the second experiment examining neural correlates of effort- and reward-processing in a cannabis using population, findings indicate fronto-striatal but also posterior cortical processing alterations during prospective signaling of effort and reward signals and during effort-reward information integration. In the final experiment assessing the effects of childhood trauma on acute stress responses and gambling urges in a population of problem gamblers, increased reports of childhood trauma were noted relative to a healthy control group. Childhood trauma subsequently predicted subjective and physiological stress responses, and emotional and physical neglect in childhood was further linked to increased gambling urges. Taken as a whole, these studies suggest that emotions plays a crucial role in moderating various components of EBDM, underscoring the significant impact of emotional states on higher-order cognitive functioning. / Dissertation / Doctor of Philosophy (PhD)
| Identifer | oai:union.ndltd.org:mcmaster.ca/oai:macsphere.mcmaster.ca:11375/30055 |
| Date | January 2024 |
| Creators | Brassard, Sarah |
| Contributors | Balodis, Iris, Neuroscience |
| Source Sets | McMaster University |
| Language | English |
| Detected Language | English |
| Type | Thesis |
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